Key findings in trisomy 21 Physical traits - include upslanting palpebral fissures, flat nasal bridge and midface, decreased muscle tone (hypotonia), wider space between first and second toe ("sandal gap"), nystagmus, brachycephaly, incurving of the fifth finger (clinodactyly), narrow palate, overfolded helix of the ear (especially with a small ear), short-appearing neck with redundant.. PMID: 21477544. The use of second-trimester genetic sonogram in guiding clinical management of patients at increased risk for fetal trisomy 21. Vintzileos AM, Campbell WA, Rodis JF, Guzman ER, Smulian JC, Knuppel RAObstet Gynecol 1996 Jun;87 (6):948-52. doi: 10.1016/0029-7844 (96)00053-1. PMID: 8649704.

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Another physical finding in many infants with Down's syndrome is an increased gap between the

A sandal gap deformity, also known as hallux varus, is an imaging observation in antenatal ultrasound (typically second trimester) where there is an expanded first interspace, i.e. the gap between the great toe of the foot from the rest of the toes (likened to the gap caused by a sandal).. While it can be a normal variant (especially when it is the only finding) it is also sometimes considered.. Authoring team. Sandal Gap. a descriptive term for a large gap between the large toe and the first toe, it is often a sign of an underlying genetic condition such as Down's syndrome but other conditions including Bardet-Biedl syndrome can present with a large sandal gap.