Obagi Tretinoin. Obagi Tretinoin is a potent type of Vitamin A that works deep within the skin to help address and prevent acne. Available in multiple strengths to meet different needs, this powerful acne treatment has been clinically proven to improve breakout symptoms and prevent the development of acne. Prescription required.. Obagi Tretinoin cream is an active form of vitamin A. It is one of the most powerful and effective topical treatments in skincare. Tretinoin is used for the treatment of acne, hyperpigmentation and signs of ageing. It is a prescription topical and is available in 3 strengths of Tretinoin 0.025, 0.05, and 0.1 cream.

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